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- B7a7781d69c25dce410d529c80946809c NCIT_P378 "NCI" @default.
- B7a7781d69c25dce410d529c80946809c type Axiom @default.
- B7a7781d69c25dce410d529c80946809c annotatedProperty IAO_0000115 @default.
- B7a7781d69c25dce410d529c80946809c annotatedSource NCIT_C200464 @default.
- B7a7781d69c25dce410d529c80946809c annotatedTarget "A radiotracer composed of RAD301, which comprises an integrin alphaVbeta6 (aVb6) binding peptide (BP) and is radiolabeled with the radionuclide gallium Ga 68, with potential integrin aVb6 imaging activity using positron emission tomography (PET). Upon administration of gallium Ga 68-labeled alphaVbeta6 binding peptide RAD301, the aVb6-binding peptide moiety selectively targets and binds to integrin aVb6-positive cancer cells. During PET, aVb6-expressing tumor cells can be visualized and the degree of tumor growth can be determined. Integrin aVb6, a cell adhesion and signaling receptor, is upregulated in certain cancer cell types and has been associated with increased proliferation, migration and invasion of tumor cells." @default.