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- B7b0e277398e64a65e43426d37c17376a NCIT_P378 "NCI" @default.
- B7b0e277398e64a65e43426d37c17376a type Axiom @default.
- B7b0e277398e64a65e43426d37c17376a annotatedProperty IAO_0000115 @default.
- B7b0e277398e64a65e43426d37c17376a annotatedSource NCIT_C38567 @default.
- B7b0e277398e64a65e43426d37c17376a annotatedTarget "Encoded by human NOS2B Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2B binds FAD and FMN cofactors, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2B may bind SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. (NCI)" @default.