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- B7b8f03f7dee44eef500e8d7836672c1b NCIT_P378 "NCI" @default.
- B7b8f03f7dee44eef500e8d7836672c1b type Axiom @default.
- B7b8f03f7dee44eef500e8d7836672c1b annotatedProperty IAO_0000115 @default.
- B7b8f03f7dee44eef500e8d7836672c1b annotatedSource NCIT_C75124 @default.
- B7b8f03f7dee44eef500e8d7836672c1b annotatedTarget "A 9-aza-anthrapyrazole antineoplastic antibiotic. Topixantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Compared to other DNA intercalators, this agent shows minimal cardiotoxicity." @default.