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- B7c706cc911e899d68bddc7923341753c NCIT_P378 "NCI" @default.
- B7c706cc911e899d68bddc7923341753c type Axiom @default.
- B7c706cc911e899d68bddc7923341753c annotatedProperty IAO_0000115 @default.
- B7c706cc911e899d68bddc7923341753c annotatedSource NCIT_C504 @default.
- B7c706cc911e899d68bddc7923341753c annotatedTarget "A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)" @default.