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- B7ca367c8814f04f8f31b293b1b59e323 NCIT_P378 "NCI" @default.
- B7ca367c8814f04f8f31b293b1b59e323 type Axiom @default.
- B7ca367c8814f04f8f31b293b1b59e323 annotatedProperty IAO_0000115 @default.
- B7ca367c8814f04f8f31b293b1b59e323 annotatedSource NCIT_C66133 @default.
- B7ca367c8814f04f8f31b293b1b59e323 annotatedTarget "The fumarate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction, and consequently a diminished cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thereby preventing vasoconstriction and aldosterone secretion." @default.