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- B7cadb950f06c958ae366984417866a30 NCIT_P378 "NCI" @default.
- B7cadb950f06c958ae366984417866a30 type Axiom @default.
- B7cadb950f06c958ae366984417866a30 annotatedProperty IAO_0000115 @default.
- B7cadb950f06c958ae366984417866a30 annotatedSource NCIT_C236 @default.
- B7cadb950f06c958ae366984417866a30 annotatedTarget "The hydrochloride salt of an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors." @default.