Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B7d39b74b204e5f18e0fef6e9c1ca6de0> ?p ?o ?g. }
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- B7d39b74b204e5f18e0fef6e9c1ca6de0 NCIT_P378 "NCI" @default.
- B7d39b74b204e5f18e0fef6e9c1ca6de0 type Axiom @default.
- B7d39b74b204e5f18e0fef6e9c1ca6de0 annotatedProperty IAO_0000115 @default.
- B7d39b74b204e5f18e0fef6e9c1ca6de0 annotatedSource NCIT_C37454 @default.
- B7d39b74b204e5f18e0fef6e9c1ca6de0 annotatedTarget "A phosphorothioate oligonucleotide harboring nucleotide sequences complementary to tumor suppressor p53 mRNA. Cenersen hybridizes with p53 mRNA molecules, and induces Rnase H dependent hydrolysis of p53 transcripts in the double stranded section of the hybrids, thereby resulting in loss of p53 production. Loss of p53 activity leads to sensitization of cancer cells to other therapeutics." @default.