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- B7d87894fa9372b84083384fb5da9cd62 NCIT_P378 "NCI" @default.
- B7d87894fa9372b84083384fb5da9cd62 type Axiom @default.
- B7d87894fa9372b84083384fb5da9cd62 annotatedProperty IAO_0000115 @default.
- B7d87894fa9372b84083384fb5da9cd62 annotatedSource NCIT_C186366 @default.
- B7d87894fa9372b84083384fb5da9cd62 annotatedTarget "A bispecific antibody and novel T cell engager1 (nTCE) targeting both the tumor-associated antigen (TAA) CD20 and the CD3, a T-cell surface antigen, with potential immunomodulating and antineoplastic activities. Upon administration, anti-cd20/anti-cd3 bispecific antibody CM355 binds to both T-cells and CD20-expressing B-lineage tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against the CD20-expressing tumor B-cells. CD20 is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies." @default.