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- B7da4ebd6b19a971be21a52085ccf154d NCIT_P378 "NCI" @default.
- B7da4ebd6b19a971be21a52085ccf154d type Axiom @default.
- B7da4ebd6b19a971be21a52085ccf154d annotatedProperty IAO_0000115 @default.
- B7da4ebd6b19a971be21a52085ccf154d annotatedSource NCIT_C163023 @default.
- B7da4ebd6b19a971be21a52085ccf154d annotatedTarget "A cancer vaccine containing epidermal growth factor (EGF), with immunomodulating and antineoplastic activities. Upon administration of the EGF vaccine EGF-PTI, EGF induces an immune response against EGFR, which results in the formation of anti-EGF-specific neutralizing antibodies. This causes binding of the anti-EGF antibodies to endogenous EGF, reduces levels of circulating EGF and prevents the binding of EGF to its receptor EGFR. This prevents EGF/EGFR pathway activation and may result in an inhibition of proliferation in EGFR-overexpressing tumor cells. EGF/EGFR-mediated signaling is overactivated in certain cancer types and drives tumor cell proliferation and progression." @default.