Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B7dbc02e91277deef8564ab3e05045e06> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B7dbc02e91277deef8564ab3e05045e06 NCIT_P378 "NCI" @default.
- B7dbc02e91277deef8564ab3e05045e06 type Axiom @default.
- B7dbc02e91277deef8564ab3e05045e06 annotatedProperty IAO_0000115 @default.
- B7dbc02e91277deef8564ab3e05045e06 annotatedSource NCIT_C176044 @default.
- B7dbc02e91277deef8564ab3e05045e06 annotatedTarget "The lactate form of panobinostat, a pan histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon administration, panobinostat selectively targets, binds to and inhibits HDAC, which induces hyperacetylation of core histone proteins. The accumulation of highly acetylated histones leads to chromatin remodeling, an altered pattern of gene expression, inhibition of tumor oncogene transcription and the selective transcription of tumor suppressor genes. This results in the inhibition of tumor cell division and the induction of tumor cell apoptosis. HDAC, upregulated in many tumor cell types, is an enzyme family that deacetylates histone proteins." @default.