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- B7e532474ed60f926a2db75264b82d4e8 NCIT_P378 "NCI" @default.
- B7e532474ed60f926a2db75264b82d4e8 type Axiom @default.
- B7e532474ed60f926a2db75264b82d4e8 annotatedProperty IAO_0000115 @default.
- B7e532474ed60f926a2db75264b82d4e8 annotatedSource NCIT_C61677 @default.
- B7e532474ed60f926a2db75264b82d4e8 annotatedTarget "A synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX)." @default.