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- B7f0aff04731800b9138a013998e911af NCIT_P378 "NCI" @default.
- B7f0aff04731800b9138a013998e911af type Axiom @default.
- B7f0aff04731800b9138a013998e911af annotatedProperty IAO_0000115 @default.
- B7f0aff04731800b9138a013998e911af annotatedSource NCIT_C104413 @default.
- B7f0aff04731800b9138a013998e911af annotatedTarget "An orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K) with potential antineoplastic activity. PI3K-delta inhibitor TGR-1202 inhibits PI3K and prevents the activation of the PI3K/AKT kinase signaling pathway. This decreases proliferation and induces cell death in susceptible tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in tumor cells and cells of the hematopoietic lineage. The targeted inhibition of PI3K-delta allows for PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival." @default.