Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B7f3913f98fe777a69d5efb0b2ab2e0d7> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B7f3913f98fe777a69d5efb0b2ab2e0d7 NCIT_P378 "NCI" @default.
- B7f3913f98fe777a69d5efb0b2ab2e0d7 type Axiom @default.
- B7f3913f98fe777a69d5efb0b2ab2e0d7 annotatedProperty IAO_0000115 @default.
- B7f3913f98fe777a69d5efb0b2ab2e0d7 annotatedSource NCIT_C185853 @default.
- B7f3913f98fe777a69d5efb0b2ab2e0d7 annotatedTarget "An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the tumor-associated antigen (TAA) claudin 18.2 (CLDN18.2; A2 isoform of claudin-18) conjugated via a cleavable linker, to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration, anti-CLDN18.2 ADC LM-302 specifically targets and binds to CLDN18.2 expressed on tumor cells. Upon internalization and the release of MMAE, MMAE targets and binds to tubulin, and inhibits microtubule polymerization. This results in G2/M phase cell cycle arrest and apoptosis in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.