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- B7f3fe658f1295ea817654165ea98f951 NCIT_P378 "NCI" @default.
- B7f3fe658f1295ea817654165ea98f951 type Axiom @default.
- B7f3fe658f1295ea817654165ea98f951 annotatedProperty IAO_0000115 @default.
- B7f3fe658f1295ea817654165ea98f951 annotatedSource NCIT_C131909 @default.
- B7f3fe658f1295ea817654165ea98f951 annotatedTarget "An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. EGFR T790M antagonist BPI-15086 specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.