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- B7f5ea85a23bb522521b5dbc890c9c8ac NCIT_P378 "NCI" @default.
- B7f5ea85a23bb522521b5dbc890c9c8ac type Axiom @default.
- B7f5ea85a23bb522521b5dbc890c9c8ac annotatedProperty IAO_0000115 @default.
- B7f5ea85a23bb522521b5dbc890c9c8ac annotatedSource NCIT_C14044 @default.
- B7f5ea85a23bb522521b5dbc890c9c8ac annotatedTarget "Around 70 amino acids and weakly conserved, the PWWP Domain is named after a conserved Pro-Trp-Trp-Pro motif often found as multiple copies in proteins that contain chromatin-association domains or in cell growth and differentiation transcription factors, such as WHSC1 (C-terminus) and ASH1/Trithorax Group proteins. Although its function is unknown, the amino acid composition suggests that it may be involved in protein-protein interactions. The domain N-terminal half resembles a barrel-like five-stranded structure; the C-terminal half contains a five-helix bundle. The halves form a module that exhibits positive electrostatic potential. Alone, the domain binds DNA in vitro, probably through its basic surface. (NCI)" @default.