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- B803a3878fe3c293c8705cdb482413b8d NCIT_P378 "NCI" @default.
- B803a3878fe3c293c8705cdb482413b8d type Axiom @default.
- B803a3878fe3c293c8705cdb482413b8d annotatedProperty IAO_0000115 @default.
- B803a3878fe3c293c8705cdb482413b8d annotatedSource NCIT_C1837 @default.
- B803a3878fe3c293c8705cdb482413b8d annotatedTarget "The hydrochloride salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Paroxetine binds to the pre-synaptic serotonin transporter complex resulting in negative allosteric modulation of the complex thereby blocking reuptake of serotonin by the pre-synaptic transporter. Inhibition of serotonin recycling enhances serotonergic function through serotonin accumulation in the synaptic cleft, resulting in long-term desensitization and downregulation of 5HT1 (serotonin) receptors and leading to symptomatic relief of depressive illness." @default.