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- B80474547c0bd923597c68a789a1fa6b4 NCIT_P378 "NCI" @default.
- B80474547c0bd923597c68a789a1fa6b4 type Axiom @default.
- B80474547c0bd923597c68a789a1fa6b4 annotatedProperty IAO_0000115 @default.
- B80474547c0bd923597c68a789a1fa6b4 annotatedSource NCIT_C3868 @default.
- B80474547c0bd923597c68a789a1fa6b4 annotatedTarget "A stromal tumor most commonly seen in the gastrointestinal tract. Rare cases of solitary masses in the omentum or the mesentery have also been reported (extragastrointestinal gastrointestinal stromal tumor). It is a tumor that differentiates along the lines of interstitial cells of Cajal. Most cases contain KIT- or PDGFRA-activating mutations. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. Conventional chemotherapy and radiation therapy have been of limited value. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases." @default.