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- B813c4ce3b5c3ce9585114e2138cdb52c NCIT_P378 "NCI" @default.
- B813c4ce3b5c3ce9585114e2138cdb52c type Axiom @default.
- B813c4ce3b5c3ce9585114e2138cdb52c annotatedProperty IAO_0000115 @default.
- B813c4ce3b5c3ce9585114e2138cdb52c annotatedSource NCIT_C20544 @default.
- B813c4ce3b5c3ce9585114e2138cdb52c annotatedTarget "The three subunits of the TFIIA complex (alpha, bet, and gamma) are encoded by the GTF2A1 and GTF2A2 genes. TFIIA has multiple roles in transcription initiation by RNA polymerase II. First, the association of TFIIA and TBP stabilizes the TBP-TATA element interaction. In so doing, TFIIA also stimulates transcription by displacing TBP-associated repressors and counteracts the ability to inhibit TBP binding to DNA. Second, TFIIA serves as a cofactor for the activators and coactivators. Third, TFIIA is required for the isomerization and extension of TFIID-promoter contacts and for stabilizing interactions between TFIID and initiator sequences. (from PMID 10364255)" @default.