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- B8168b5f8611fd0a2808bf99acabdfbd4 NCIT_P378 "NCI" @default.
- B8168b5f8611fd0a2808bf99acabdfbd4 type Axiom @default.
- B8168b5f8611fd0a2808bf99acabdfbd4 annotatedProperty IAO_0000115 @default.
- B8168b5f8611fd0a2808bf99acabdfbd4 annotatedSource NCIT_C71717 @default.
- B8168b5f8611fd0a2808bf99acabdfbd4 annotatedTarget "A second-generation, orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A kinase with potential antineoplastic activity. Alisertib binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aberrant expression of Aurora kinases occurs in a wide variety of cancers, including colon and breast cancers." @default.