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- B8258264da1e5b02b8a1c93ea056b203d NCIT_P378 "NCI" @default.
- B8258264da1e5b02b8a1c93ea056b203d type Axiom @default.
- B8258264da1e5b02b8a1c93ea056b203d annotatedProperty IAO_0000115 @default.
- B8258264da1e5b02b8a1c93ea056b203d annotatedSource NCIT_C103150 @default.
- B8258264da1e5b02b8a1c93ea056b203d annotatedTarget "A specific biomarker of hypochlorous acid (HClO), the oxidation product of myeloperoxidase (MPO). Under oxidative stress, 3-chlorotyrosine is produced in proteins with tyrosine residues by the strong oxidant HClO. HClO which is formed at sites of inflammation is also the anti-bacterial molecule produced by neutrophils through MPO-catalyzed oxidation. MPO is a heme-containing enzyme secreted by activated neutrophils and monocytes; it is the only enzyme that produces HClO. Therefore, 3-chlorotyrosine can potentially be used to help determine the extent of neutrophilic inflammation." @default.