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- B827b2e8b462e59d45d4b4fbc3c05794d NCIT_P378 "NCI" @default.
- B827b2e8b462e59d45d4b4fbc3c05794d type Axiom @default.
- B827b2e8b462e59d45d4b4fbc3c05794d annotatedProperty IAO_0000115 @default.
- B827b2e8b462e59d45d4b4fbc3c05794d annotatedSource NCIT_C2542 @default.
- B827b2e8b462e59d45d4b4fbc3c05794d annotatedTarget "Cells isolated from lymph nodes from patients, and activated in vitro to generate tumor-specific effector T cells. Lymph nodes in the lymphatics draining tumors often contain T cells that are immunologically sensitized but functionally deficient. Vaccine-sensitized draining lymph node cells are prepared by isolating these lymphocytes in vitro and stimulating them with cytokines to differentiate into mature effector cells. Vaccine-draining lymph node cells may also be produced by pharmacological activation of lymph node-derived lymphocytes with drugs such as ionomycin or with bacterial toxin; these activated lymphocytes may be expanded in culture with cytokines such as interleukin-2 prior to infusion into the patient. (NCI04)" @default.