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- B829c3229453ba11d5cf4301b4c5a9057 NCIT_P378 "NCI" @default.
- B829c3229453ba11d5cf4301b4c5a9057 type Axiom @default.
- B829c3229453ba11d5cf4301b4c5a9057 annotatedProperty IAO_0000115 @default.
- B829c3229453ba11d5cf4301b4c5a9057 annotatedSource NCIT_C65475 @default.
- B829c3229453ba11d5cf4301b4c5a9057 annotatedTarget "A dibenzoxepin derivative and tricyclic antidepressant (TCA) with antipruritic, antidepressive and anxiolytic activities. Doxepin blocks the reuptake of norepinephrine and serotonin (5-HT) into presynaptic terminals thereby prolonging the availability of the monoaminergic neurotransmitters within the synaptic cleft and enhancing their neurotransmission. Doxepin also has antagonistic effects on histamine H1, 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is mediated through inhibition of histamine receptors." @default.