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- B82a338e4b8a31f177e6f9413364ce218 NCIT_P378 "NCI" @default.
- B82a338e4b8a31f177e6f9413364ce218 type Axiom @default.
- B82a338e4b8a31f177e6f9413364ce218 annotatedProperty IAO_0000115 @default.
- B82a338e4b8a31f177e6f9413364ce218 annotatedSource NCIT_C28860 @default.
- B82a338e4b8a31f177e6f9413364ce218 annotatedTarget "A vaccine consisting of replication-defective recombinant adenovirus that encodes for Bcl-Xs with potential antineoplastic activity. Vaccination with Bcl-Xs adenovirus vaccine induces apoptosis in Bcl-2 and Bcl-XL positive cancer cells, resulting in decreased tumor growth while leaving normal cells unaffected. Bcl-Xs block the function of the protooncogenes Bcl-2 and Bcl-XL which are overexpressed in a variety of solid tumors and promote cancer cell survival by inhibiting apoptosis. (NCI04)" @default.