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- B82c0974bfd267fd68b3ebc93c2528a6f NCIT_P378 "NCI" @default.
- B82c0974bfd267fd68b3ebc93c2528a6f type Axiom @default.
- B82c0974bfd267fd68b3ebc93c2528a6f annotatedProperty IAO_0000115 @default.
- B82c0974bfd267fd68b3ebc93c2528a6f annotatedSource NCIT_C29245 @default.
- B82c0974bfd267fd68b3ebc93c2528a6f annotatedTarget "The hydrochloride salt form of meclizine, a synthetic piperazine with anti-emetic, sedative and histamine H1 antagonistic properties. Meclizine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Meclizine hydrochloride may exert its antiemetic effects by its anticholinergic actions or due to a direct effect on the medullary chemoreceptive trigger zone." @default.