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- B837751f2ac95a50db403ee33617d74a8 NCIT_P378 "BIOCARTA" @default.
- B837751f2ac95a50db403ee33617d74a8 type Axiom @default.
- B837751f2ac95a50db403ee33617d74a8 annotatedProperty NCIT_P325 @default.
- B837751f2ac95a50db403ee33617d74a8 annotatedSource NCIT_C39191 @default.
- B837751f2ac95a50db403ee33617d74a8 annotatedTarget "The amyloid-beta peptide (Ab), a proteolytic fragment of amyloid precursor protein (APP), is the major component of senile plaques, the hallmark of Alzheimer's disease. Platelets contain both APP and Ab and probably contribute greater than 90% of circulating APP. The soluble APP is the major inhibitor of coagulation factors IXa and XIa, and platelet aggregation. Agonists such as ADP, thrombin, epinephrine and collagen activate the release of APP and plasminogen activator inhibitor I (an important regulator of coagulation) from platelet storage granules. These important molecules released from platelets are key regulators of hemostasis, the physiologic arrest of hemorrhage at site of vascular leakage. (This definition may be outdated - see the DesignNote.)" @default.