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- B8441c2e86bc794b30df1f11f2dc29dd6 NCIT_P378 "NCI" @default.
- B8441c2e86bc794b30df1f11f2dc29dd6 type Axiom @default.
- B8441c2e86bc794b30df1f11f2dc29dd6 annotatedProperty IAO_0000115 @default.
- B8441c2e86bc794b30df1f11f2dc29dd6 annotatedSource NCIT_C239 @default.
- B8441c2e86bc794b30df1f11f2dc29dd6 annotatedTarget "A broad-spectrum, semi-synthetic, beta-lactam penicillin antibiotic with bactericidal activity. Ampicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Ampicillin is stable against hydrolysis by a variety of beta-lactamases, therefore, can be used in wide range of gram-positive and -negative infections." @default.