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- B84c3765e25cf61fd462e0a233082ded2 NCIT_P378 "NCI" @default.
- B84c3765e25cf61fd462e0a233082ded2 type Axiom @default.
- B84c3765e25cf61fd462e0a233082ded2 annotatedProperty IAO_0000115 @default.
- B84c3765e25cf61fd462e0a233082ded2 annotatedSource NCIT_C112004 @default.
- B84c3765e25cf61fd462e0a233082ded2 annotatedTarget "An orally available inhibitor of the serine/threonine protein kinases ribosomal protein S6 Kinase (p70S6K) and Akt (protein kinase B), with potential antineoplastic activity. Upon administration, p70S6K/Akt inhibitor M-2698 binds to and inhibits the activity of p70S6K and Akt. This prevents the activation of the PI3K/Akt/p70S6K signaling pathway and inhibits tumor cell proliferation in cancer cells that have an overactivated PI3K/Akt/p70S6K signaling pathway. Constitutive activation and dysregulated signaling of the PI3K/Akt/p70S6K pathway are frequently associated with tumorigenesis of many tumor types; targeting multiple kinases in this pathway is more efficacious than targeting a single kinase." @default.