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- B84f16997651b7b417cfc9d6fa606ead2 NCIT_P378 "BIOCARTA" @default.
- B84f16997651b7b417cfc9d6fa606ead2 type Axiom @default.
- B84f16997651b7b417cfc9d6fa606ead2 annotatedProperty NCIT_P325 @default.
- B84f16997651b7b417cfc9d6fa606ead2 annotatedSource NCIT_C39104 @default.
- B84f16997651b7b417cfc9d6fa606ead2 annotatedTarget "In most animal species, the anteroposterior body axis is generated by the formation of repeated structures called segments. In vertebrate segmentation, a specialized mesodermal structure called the somite gives rise to skeletal muscles, vertebrae, and some dermis. Formation of the somites is a rhythmic process that involves an oscillator, the segmentation clock, driven by Wnt and Notch signaling. The clock ticks in somite precursors and halts when they reach a specific maturation stage defined as the wavefront, established by FGF and Wnt signaling. Lunatic fringe was shown to act downstream of Notch and to bind and negatively regulate its own promoter. Another cyclic gene is hes1. It acts also downstream of Notch and codes for an unstable protein able to negatively regulate its own promoter too. (This definition may be outdated - see the DesignNote.)" @default.