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- B85099aa75e5f6d1f109b62d414158fda NCIT_P378 "NCI" @default.
- B85099aa75e5f6d1f109b62d414158fda type Axiom @default.
- B85099aa75e5f6d1f109b62d414158fda annotatedProperty IAO_0000115 @default.
- B85099aa75e5f6d1f109b62d414158fda annotatedSource NCIT_C1196 @default.
- B85099aa75e5f6d1f109b62d414158fda annotatedTarget "A 2-nitroimidazole with hypoxic selectivity and potential radiosensitizing activities. Pimonidazole is reduced in hypoxic environments such as those found in tumors. In hypoxic cells, reduced pimonidazole binds to thiol-containing proteins. The resulting complexes accumulate in hypoxic tumors, thereby depleting radioprotective thiol compounds and sensitizing tumor cells to be more susceptible for radiation treatment." @default.