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- B851d39bb9c4779bf774115998316b1ac NCIT_P378 "NCI" @default.
- B851d39bb9c4779bf774115998316b1ac type Axiom @default.
- B851d39bb9c4779bf774115998316b1ac annotatedProperty IAO_0000115 @default.
- B851d39bb9c4779bf774115998316b1ac annotatedSource NCIT_C62047 @default.
- B851d39bb9c4779bf774115998316b1ac annotatedTarget "A local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts its antiarrhythmic effect by inhibiting the inward sodium current in cardiac cells, thereby reducing the rate of rise of the cardiac action potential (phase 0) and decreases automaticity in the Purkinje fibers. This slows nerve impulses in the heart and stabilizes the heartbeat. Mexiletine's anesthetic activity is due to its ability to block sodium influx in peripheral nerves, thereby reducing the rate and intensity of pain impulses reaching the central nervous system." @default.