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- B853790e066fa8b934a416fb3ec86b496 NCIT_P378 "NCI" @default.
- B853790e066fa8b934a416fb3ec86b496 type Axiom @default.
- B853790e066fa8b934a416fb3ec86b496 annotatedProperty IAO_0000115 @default.
- B853790e066fa8b934a416fb3ec86b496 annotatedSource NCIT_C103859 @default.
- B853790e066fa8b934a416fb3ec86b496 annotatedTarget "A human monoclonal antibody directed against the human epidermal growth factor receptor ErbB3 (Her3) with potential antineoplastic activity. Upon administration, anti-ErbB3 monoclonal antibody REGN1400 binds to ErbB3 and prevents neuregulin 1 ligand binding to ErbB3, which may result in an inhibition of ErbB3-dependent phosphatidylinositol-3 kinase (PI3K)/Akt signaling. This eventually leads to the inhibition of cellular proliferation and differentiation. ErbB3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed in a variety of solid tumors and its overexpression generally correlates with poor prognosis and tumor resistance." @default.