Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B85bcedeb8bb848a04792dbcd22841ed5> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B85bcedeb8bb848a04792dbcd22841ed5 NCIT_P378 "NCI" @default.
- B85bcedeb8bb848a04792dbcd22841ed5 type Axiom @default.
- B85bcedeb8bb848a04792dbcd22841ed5 annotatedProperty IAO_0000115 @default.
- B85bcedeb8bb848a04792dbcd22841ed5 annotatedSource NCIT_C191757 @default.
- B85bcedeb8bb848a04792dbcd22841ed5 annotatedTarget "An engineered monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2 monoclonal antibody ZL-1211 specifically targets and binds to CLDN18.2 expressed on tumor cells. The binding induces antibody-dependent cellular cytotoxicity (ADCC) and activates innate and adaptive immunity. This kills and inhibits proliferation of CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.