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- B863a010c9fdbf218c6eb154b5ac14744 NCIT_P378 "NCI" @default.
- B863a010c9fdbf218c6eb154b5ac14744 type Axiom @default.
- B863a010c9fdbf218c6eb154b5ac14744 annotatedProperty IAO_0000115 @default.
- B863a010c9fdbf218c6eb154b5ac14744 annotatedSource NCIT_C201279 @default.
- B863a010c9fdbf218c6eb154b5ac14744 annotatedTarget "The most abundant immunoglobulin G (IgG) subclass in the circulation of healthy individuals. The IgG1 core hinge sequence contains 15 amino acids and two interchain disulfide bonds. This subtype has high affinity for binding both Fc receptors and complement component C1q. IgG1 is the predominant antibody subclass that responds to antigens derived from both soluble and membrane proteins. Reduced levels of circulating IgG1 can indicate the presence of a variety of primary and secondary antibody deficiencies, which can result in hypogammaglobulinemia." @default.