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- B8653bd748a84653ae809a6c07b1f6f59 NCIT_P378 "NCI" @default.
- B8653bd748a84653ae809a6c07b1f6f59 type Axiom @default.
- B8653bd748a84653ae809a6c07b1f6f59 annotatedProperty IAO_0000115 @default.
- B8653bd748a84653ae809a6c07b1f6f59 annotatedSource NCIT_C20573 @default.
- B8653bd748a84653ae809a6c07b1f6f59 annotatedTarget "Human HMGA Family Genes encode HMGA proteins that participate in many nuclear processes ranging from chromosome and chromatin mechanics to transcription factors that regulate gene expression. Hence, they influence diverse biological processes including cell growth, proliferation, differentiation and death. HMGA proteins contain three AT-hooks that bind to minor groove AT-rich stretches. HMGA proto-oncogenes promote tumor progression and metastasis when overexpressed. High constitutive HMGA expression is consistently observed in cancers, with increasing concentrations being correlated with increasing malignancy. (NCI)" @default.