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- B86c0dc53330044ef85647b2fa0dc1a68 NCIT_P378 "NCI" @default.
- B86c0dc53330044ef85647b2fa0dc1a68 type Axiom @default.
- B86c0dc53330044ef85647b2fa0dc1a68 annotatedProperty IAO_0000115 @default.
- B86c0dc53330044ef85647b2fa0dc1a68 annotatedSource NCIT_C62070 @default.
- B86c0dc53330044ef85647b2fa0dc1a68 annotatedTarget "A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)" @default.