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- B872c57be5350f98bb18aaca3f7229a94 NCIT_P378 "NCI" @default.
- B872c57be5350f98bb18aaca3f7229a94 type Axiom @default.
- B872c57be5350f98bb18aaca3f7229a94 annotatedProperty IAO_0000115 @default.
- B872c57be5350f98bb18aaca3f7229a94 annotatedSource NCIT_C1254 @default.
- B872c57be5350f98bb18aaca3f7229a94 annotatedTarget "A synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo. (NCI04)" @default.