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- B8781452de0fb58912df23a66e8f6857c NCIT_P378 "NCI" @default.
- B8781452de0fb58912df23a66e8f6857c type Axiom @default.
- B8781452de0fb58912df23a66e8f6857c annotatedProperty IAO_0000115 @default.
- B8781452de0fb58912df23a66e8f6857c annotatedSource NCIT_C870 @default.
- B8781452de0fb58912df23a66e8f6857c annotatedTarget "A synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. Thalidomide acts primarily by inhibiting both the production of tumor necrosis factor alpha (TNF-alpha) in stimulated peripheral monocytes and the activities of interleukins and interferons. This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In addition, thalidomide inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), thereby inhibiting angiogenesis." @default.