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- B8791893b324848e83513d1e71e34159c NCIT_P378 "NCI" @default.
- B8791893b324848e83513d1e71e34159c type Axiom @default.
- B8791893b324848e83513d1e71e34159c annotatedProperty IAO_0000115 @default.
- B8791893b324848e83513d1e71e34159c annotatedSource NCIT_C1112 @default.
- B8791893b324848e83513d1e71e34159c annotatedTarget "A benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus. Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be over-expressed or overactive in tumor cells. (NCI04)" @default.