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- B8791e38dd0cbb8cbe882b8b517740598 NCIT_P378 "NCI" @default.
- B8791e38dd0cbb8cbe882b8b517740598 type Axiom @default.
- B8791e38dd0cbb8cbe882b8b517740598 annotatedProperty IAO_0000115 @default.
- B8791e38dd0cbb8cbe882b8b517740598 annotatedSource NCIT_C2829 @default.
- B8791e38dd0cbb8cbe882b8b517740598 annotatedTarget "The hydrochloride salt form of fluoxetine, a diphenhydramine derivative and selective serotonin reuptake inhibitor with antidepressant, anti-anxiety, antiobsessional and antibulimic activity and with potential immunomodulating activity. Upon administration, fluoxetine binds to the presynaptic serotonin (5-HT) receptor resulting in negative allosteric modulation of the receptor complex, thereby blocking recycling of serotonin by the presynaptic receptor. Inhibition of serotonin reuptake by fluoxetine enhances serotonergic function through serotonin accumulation in the synaptic space, resulting in long-term desensitization and downregulation of 5-HT receptors, preventing 5-HT-mediated signaling and leading to antidepressant, anti-anxiety, antiobsessional and antibulimic effects. In addition, fluoxetine may inhibit the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6). This may prevent IL-6-mediated inflammation and cytokine storm." @default.