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- B879fb06fc1cef1737da21d6896cfebdf NCIT_P378 "NCI" @default.
- B879fb06fc1cef1737da21d6896cfebdf type Axiom @default.
- B879fb06fc1cef1737da21d6896cfebdf annotatedProperty IAO_0000115 @default.
- B879fb06fc1cef1737da21d6896cfebdf annotatedSource NCIT_C65245 @default.
- B879fb06fc1cef1737da21d6896cfebdf annotatedTarget "A prodrug of ampicillin, a broad-spectrum, semisynthetic, beta-lactam aminopenicillin antibiotic with bactericidal activity. Bacampicillin is hydrolyzed in vivo by esterases to its active metabolite ampicillin. Ampicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis." @default.