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- B87c8f4cd65a27af1acbcb90ad5cd1ef3 NCIT_P378 "NCI" @default.
- B87c8f4cd65a27af1acbcb90ad5cd1ef3 type Axiom @default.
- B87c8f4cd65a27af1acbcb90ad5cd1ef3 annotatedProperty IAO_0000115 @default.
- B87c8f4cd65a27af1acbcb90ad5cd1ef3 annotatedSource NCIT_C61741 @default.
- B87c8f4cd65a27af1acbcb90ad5cd1ef3 annotatedTarget "The disodium salt form of edetate, a heavy metal chelating agent with anti-hypercalcemic and anti-arrhythmic properties. Edetate, a heavy metal antagonist, chelates divalent and trivalent metals, forming soluble stable complexes which are readily excreted by the kidneys, thereby can be used to lower serum calcium concentrations. In addition, this agent exerts a negative inotropic effect on the heart through a transiently induced hypocalcemic state, thereby antagonizing the inotropic and chronotropic effects of digitalis glycosides on the ventricles of the heart. Upon ocular administration, edetate exerts its ophthalmic effect by chelating calcium to form soluble complexes, thereby removing corneal calcium deposits." @default.