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- B87d1047ce833c93f8c14daf9ebb3d3c5 NCIT_P378 "NCI" @default.
- B87d1047ce833c93f8c14daf9ebb3d3c5 type Axiom @default.
- B87d1047ce833c93f8c14daf9ebb3d3c5 annotatedProperty IAO_0000115 @default.
- B87d1047ce833c93f8c14daf9ebb3d3c5 annotatedSource NCIT_C2721 @default.
- B87d1047ce833c93f8c14daf9ebb3d3c5 annotatedTarget "A synthetic, 20-base antisense oligodeoxynucleotide that hybridizes to c-raf kinase messenger RNA. ISIS 5132 has been shown to specifically suppress Raf-1 expression both in vitro and in vivo. Raf-1 serine/threonine kinase functions as a critical effector of Ras-mediated signal transduction; constitutive activation of this pathway directly contributes to malignant transformation. (NCI04)" @default.