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- B87f007cc535d5b34bc6c58b83caf0be6 NCIT_P378 "NCI" @default.
- B87f007cc535d5b34bc6c58b83caf0be6 type Axiom @default.
- B87f007cc535d5b34bc6c58b83caf0be6 annotatedProperty IAO_0000115 @default.
- B87f007cc535d5b34bc6c58b83caf0be6 annotatedSource NCIT_C1381 @default.
- B87f007cc535d5b34bc6c58b83caf0be6 annotatedTarget "The hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent." @default.