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- B886ee36778db6e24a4063662fa7ee8ae NCIT_P378 "KEGG" @default.
- B886ee36778db6e24a4063662fa7ee8ae type Axiom @default.
- B886ee36778db6e24a4063662fa7ee8ae annotatedProperty NCIT_P325 @default.
- B886ee36778db6e24a4063662fa7ee8ae annotatedSource NCIT_C91512 @default.
- B886ee36778db6e24a4063662fa7ee8ae annotatedTarget "The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex." @default.