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- B888e573d73441885faec92a55f99a06c NCIT_P378 "NCI" @default.
- B888e573d73441885faec92a55f99a06c type Axiom @default.
- B888e573d73441885faec92a55f99a06c annotatedProperty IAO_0000115 @default.
- B888e573d73441885faec92a55f99a06c annotatedSource NCIT_C78058 @default.
- B888e573d73441885faec92a55f99a06c annotatedTarget "The sulfate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids." @default.