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- B896421c40c07fa4e6cd93db6a790f430 NCIT_P378 "NCI" @default.
- B896421c40c07fa4e6cd93db6a790f430 type Axiom @default.
- B896421c40c07fa4e6cd93db6a790f430 annotatedProperty IAO_0000115 @default.
- B896421c40c07fa4e6cd93db6a790f430 annotatedSource NCIT_C66703 @default.
- B896421c40c07fa4e6cd93db6a790f430 annotatedTarget "The disodium salt form of zoledronate, a synthetic imidazole, third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix." @default.