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- B899d58738f43416fd78d163822cbee08 NCIT_P378 "NCI" @default.
- B899d58738f43416fd78d163822cbee08 type Axiom @default.
- B899d58738f43416fd78d163822cbee08 annotatedProperty IAO_0000115 @default.
- B899d58738f43416fd78d163822cbee08 annotatedSource NCIT_C185597 @default.
- B899d58738f43416fd78d163822cbee08 annotatedTarget "A topical preparation composed of a silicone gel containing a docosahexaenoic acid derivative and cytosolic group IVA phospholipase A2 alpha (cytosolic phospholipase A2 group IVA; cPLA2a; GIVA cPLA2; Group IVA cPLA2) inhibitor, with potential anti-inflammatory activity. Upon topical application to the affected site(s), the cPLA2 inhibiting silicone-based gel AVX001 binds to and inhibits the activity of cPLA2alpha. This may inhibit cPLA2alpha-mediated inflammation. cPLA2alpha catalyzes the release of arachidonic acid from glycerophospholipids and plays a key role in various inflammatory diseases. It is overexpressed in certain cancer cells and may play a key role in proliferation, migration, and chemo-resistance." @default.