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- B89d2efa9937519f3d0d9d26203b8457e NCIT_P378 "BIOCARTA" @default.
- B89d2efa9937519f3d0d9d26203b8457e type Axiom @default.
- B89d2efa9937519f3d0d9d26203b8457e annotatedProperty NCIT_P325 @default.
- B89d2efa9937519f3d0d9d26203b8457e annotatedSource NCIT_C38975 @default.
- B89d2efa9937519f3d0d9d26203b8457e annotatedTarget "The heparan sulfate proteoglycan agrin is well known as the key assembly factor of postsynaptic differentiation at the neuromuscular junction (NMJ), but recent data suggest it also plays a direct role in the organization of the cytoskeleton in the skeletal muscle. Signaling through muscle-specific proteins such as muscle specific kinase (MuSK) and or acetylcholine receptor (AchRs)/rapsyn, agrin can activate ubiquitously expressed Rac, Cdc42, and p21-activated kinase (PAK) that are involved in actin polymerization. Agrin also engages signaling pathways of several potent oncogenes (i.e., SFK, ErbB receptors, and cortactin). (This definition may be outdated - see the DesignNote.)" @default.