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- B8a1f7cb7b4e0604d8e946d6effcbe9db NCIT_P378 "NCI" @default.
- B8a1f7cb7b4e0604d8e946d6effcbe9db type Axiom @default.
- B8a1f7cb7b4e0604d8e946d6effcbe9db annotatedProperty IAO_0000115 @default.
- B8a1f7cb7b4e0604d8e946d6effcbe9db annotatedSource NCIT_C1314 @default.
- B8a1f7cb7b4e0604d8e946d6effcbe9db annotatedTarget "A methotrexate derivative with potential antineoplastic activity. Trimetrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate also exhibits antiviral activity. (NCI04)" @default.