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- B8a5b03d0482093c16ed62d9140a5f59c hasDbXref "GOC:txnOH" @default.
- B8a5b03d0482093c16ed62d9140a5f59c hasDbXref "PMID:15020047" @default.
- B8a5b03d0482093c16ed62d9140a5f59c hasDbXref "PMID:31300188" @default.
- B8a5b03d0482093c16ed62d9140a5f59c type Axiom @default.
- B8a5b03d0482093c16ed62d9140a5f59c annotatedProperty IAO_0000115 @default.
- B8a5b03d0482093c16ed62d9140a5f59c annotatedSource GO_0051123 @default.
- B8a5b03d0482093c16ed62d9140a5f59c annotatedTarget "The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA." @default.